All the work that goes into losing weight in middle age could set you up for a longer, healthier life later, according to a new study.
A sustained weight loss of about 6.5% of body weight without medications or surgery in middle-aged people is linked to substantial long-term health benefits, said lead study author Dr. Timo Strandberg, professor of geriatric medicine at the University of Helsinki in Finland.
Those benefits included a reduction of risk for both chronic diseases and death from all causes.
The study, published Tuesday in the journal JAMA Network Open, analyzed data of about 23,000 people from three different groups across different time periods: one group from 1985 to 1988, another from 1964 to 1973, and a third between 2000 and 2013.
People who lost weight in midlife were less likely to experience heart attacks, strokes, cancer, asthma or chronic obstructive pulmonary disease in their older years, according to the study.
Those who lost weight were also less likely to have died of any cause over the next 35 years, the study found.
It’s important to note that much of the data was collected before weight loss medications or surgeries were widely available, meaning that the benefits largely came from body changes driven by alterations in diet and exercise, Strandberg said.
The study is important because it provides evidence of the relationship between weight loss and both cardiovascular disease and mortality, which hasn’t been studied enough, said Dr. Aayush Visaria, a clinical researcher and incoming instructor of medicine at Rutgers Robert Wood Johnson Medical School in New Jersey. He was not involved in the research.
BMI doesn’t tell the whole story
Although the study is strong in that it utilizes a large sample, there are some limitations when applying the results, Visaria said.
“BMI is very different across different racial ethnic groups,” Visaria said.
And BMI, which looks at weight in proportion to height, isn’t always the most accurate way to gauge body composition, he added. BMI is still used widely because it is easy to calculate, but it doesn’t differentiate based on a person’s proportion of bone or muscle, Visaria said.
The study was observational, meaning that the data can show a relationship between weight loss and a reduction in chronic disease and mortality risk, but researchers can’t say for sure that the weight loss was the factor that lowered the risk, Visaria said.
Although the researchers adjusted for other factors that could influence the risk, such as age, they did not adjust for lifestyle behaviors such as diet and physical activity, he added. Those changes could be behind the lowered risk of chronic diseases just as the weight loss itself could be, Visaria said.
Both weight loss and the behavioral changes behind it are often tied together in improving health, Strandberg noted.
Weight loss relieves conditions such as osteoarthritis, obstructive sleep apnea and fatty liver, while changes to diet and exercise have been shown to decrease cardiovascular risks, he added.